Narrowing the Relationship between Human CCR5 Gene Polymorphisms and Chagas Disease: Systematic Review and Meta-Analysis.

Our aim was to carry out a qualitative and quantitative synthesis of the influence of CCR5 genetic variants on Chagas disease (CD) through a systematic review. A total of 1197 articles were analyzed, and eleven were included in the review. A meta-analysis was conducted along with principal component analyses (PCAs). The polymorphisms found were analyzed using the SNP2TFBS tool to identify possible variants that influence the interaction with gene binding sites. Eleven studied variants were identified: rs2856758, rs2734648, rs1799987, rs1799988, rs41469351, rs1800023, rs1800024, Δ32/rs333, rs3176763, rs3087253 and rs11575815. The studies analyzed were published between 2001 and 2019, conducted in Argentina, Brazil, Spain, Colombia and Venezuela, and included Argentine, Brazilian, Colombian, Peruvian and Venezuelan patients. Eight polymorphisms were subjected to the meta-analysis, of which six were associated with the development of the cardiac form of CD: rs1799987-G/G and G/A in the dominance model and G/G in the recessiveness model; rs2856758-A/G in the codominance model; rs2734648-T/T and T/G in the dominance model; rs1799988-T/T in both the codominance and recessiveness models; rs1800023-G allele and the G/G genotype in the codominance and recessiveness models, and the G/G and G/A genotypes in the dominance model; and rs1800024-T allele. The PCA analyses were able to indicate the relationships between the alleles and the genotypes of the polymorphisms. The SNP2TFBS tool identified rs1800023 as an influencer of the Spi1 transcription factor (p < 0.05). A correlation was established between the alleles associated with the cardiac form of CD in this review, members of the C haplotype of the gene (HHC-TGTG), and the cardiac form of CD.

Meta-Analysis of the Relationship between TNF-α (-308G/A) and IL-10 (-819C/T) Gene Polymorphisms and Susceptibility to Dengue.

OBJECTIVE: This study determined whether tumor necrosis factor alpha (TNF-α) and Interleukin-10 (IL-10) polymorphisms are associated with susceptibility to dengue. METHODS: a systematic review with meta-analysis was conducted of the associations between the TNF-α (-308G/A) and IL-10 (-819C/T) polymorphisms and dengue. RESULTS: A total of eight case-controls studies involving 384 individuals with symptomatic dengue, 571 individuals with dengue hemorrhagic fever, and 995 healthy controls were considered in the meta-analysis. There was no significant association between TNF-α (-308G/A) and IL-10 (-819C/T) polymorphism and dengue in overall population. However, stratifying meta-analysis by groups, the meta-analysis revealed association between the TNF-α -308 G/G (OR: 1.62, CI: 1.02-2.57, p = 0.04) genotype and allele G (OR: 1.62, CI: 1.04-2.55, p = 0.03) that confers susceptibility to symptomatic dengue, while the TNF-α -308 G/A genotype (OR: 0.69, CI = 0.39-0.99, p = 0.04) and allele A (OR: 0.64, CI: 0.41-1.00, p = 0.05) confers protection to symptomatic dengue. No difference was observed for the TNF-α (-308) and IL-10 (-819C/T) polymorphisms in the comparisons of hemorrhagic dengue versus control and hemorrhagic dengue versus symptomatic dengue. CONCLUSION: This meta-analysis showed that TNF-α (-308) polymorphism is associated with dengue symptomatic susceptibility.

Análise epidemiológica da dengue em uma população do nordeste / Epidemiological analysis of dengue in a brazilian northeast region population / Análisis epidemiológico del dengue en una población del nordeste

Objetivo: descrever a situação epidemiológica da dengue. Método: estudo descritivo e ecológico que utilizou dados secundários dos casos notificados de dengue obtidos no Sistema Nacional de Agravos de Notificação (SINAN) durante o período de 2007 a 2013. As variáveis analisadas foram a nível temporal (ano/mês) e demográfico (sexo e faixa etária) e a taxa de infestação predial. A análise descritiva foi realizada pelo software Graphpad Prism 5.0. Resultados: dos 21.579 casos notificados, 19.686 foram classificados como dengue clássica, 98 como dengue com complicações, 44 como febre hemorrágica da dengue e 1 síndrome do choque do dengue. Predominância dos casos notificados foi do gênero feminino (12.180 casos) e dos indivíduos na faixa etária de 20-49 anos (9.978 casos). As crianças foram as mais acometidas pela febre da dengue hemorrágica (21 casos). Conclusão: estratégias de vigilância em saúde e entomológica são necessárias para o combate ao vetor da doença.(AU).

Objective: to describe the epidemiological situation of dengue. Method: descriptive and ecological study using secondary data of dengue reported cases obtained in the National Notifiable Diseases Information System (SINAN) during the period from 2007 to 2013. The variables analyzed were time (year / month) and demography (gender and age) levels and the rate of infestation. The descriptive analysis was performed using Graphpad Prism 5.0 software. Results: of the 21,579 reported cases, 19,686 were classified as dengue fever, 98 as dengue with complications, 44 as dengue hemorrhagic fever and 1 as dengue shock syndrome. The prevalence of reported cases was female (12,180 cases) and individuals aged from 20 to 49 years old (9,978 cases). The children were the most affected by dengue hemorrhagic fever (21 cases). Conclusion: surveillance health and entomological strategies are needed to combat the vector of the disease.(AU)

Objetivo: describir la situación epidemiológica del dengue. Método: estudio descriptivo y ecológico que utilizó datos secundarios de los casos notificados de dengue obtenidos en el Sistema Nacional de Problemas de Notificación (SINAN) durante el período de 2007 a 2013. Las variables analizadas fueron a nivel temporal (año/mes) y demográfico (sexo y edad) y la tasa de infestación predial. El análisis descriptivo fue realizado por el software Graphpad Prism 5.0. Resultados: de los 21.579 casos notificados, 19.686 fueron clasificados como dengue clásico, 98 como dengue con complicaciones, 44 como fiebre hemorrágica del dengue y 1 síndrome del choque del dengue. Predominancia de los casos notificados fue del género femenino (12.180 casos) y de los individuos en la edad entre 20-49 años (9.978 casos). Los niños fueron los más afectados por la fiebre del dengue hemorrágico (21 casos). Conclusión: estrategias de vigilancia en salud y entomológica son necesarias para el combate al vector de la enfermedad.(AU)